hypermethylation相关论文
Objective Deletion of the short arm of chromosome 17(del17p)is an independent prognostic marker associated with poor cli......
Helicobacter pylori induced Hypermethylation of Mist1 promotes epithelial-mesenchymal transformation
Objective The incidence of gastric adenocarcinoma is extremely high in gastrointestinal cancers,especially in East Asian......
MiR-193b regulates the tumorigenesis of esophageal cancer through ZIP5(SLC39A5)by increasing intrace
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MGMT promoter hypermethylation by CagA of Helicobacter pylori via DNA methyltransferase-1 activation
CpG island promoter methylation of tumor suppressor genes is one of the most characteristic abnormalities in Helicobacte......
Global DNA methylation was changed by a maternal high lipid and high energy diet during gestation an
前言 Epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease i......
Unlike genetic aberrations, epigenetic alterations do not modify the DNA coding sequence, and can be reversed pharmacolo......
The association of rarβ, calca, esr1 and tfp1 gene promoter hypermethylation with the cervical carci
Objectives: Cervical carcinoma is a high prevalence disease in ethnic Uyghur women in China.Recent epigenetic studies ha......
Global DNA methylation was changed by a maternal high lipid and high energy diet during gestation an
Epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease in......
Identification of cancer genes differentially expressed in hepatocellular carcinoma (HCC) will play important role i......
Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylat
AIM: To study Helicobacter pylori (H pylori) infection in relation to E-cadherin (E-cad) promoter polymorphism and hyper......
Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in ga
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Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic can
AIM:To determine the methylation status and aberrant expression of some secreted frizzled-related protein (SFRP) genes i......
AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer pati......
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,Genetic and Epigenetic Alterations of DLC-1, a Candidate Tumor Suppressor Gene, in Nasopharyngeal C
The DLC-1 gene, located at the human chromosome region 8p22, behaves like a tumor suppressor gene and is frequently dele......
Aberrant p16 promoter hypermethylation in bronchial mucosae as a biomarker for the early detection o
Lung cancer is the leading cause of cancer related death in the world and its mortality could be greatly reduced by dia......
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抑癌基因启动子过甲基化是除基因突变和染色体物质缺失外抑癌基因失活的第3种机制,某些情况下是抑癌基因失活的惟一机制.目前抑癌......
背景GATA转录因子家族在胚胎发育时期能够促进胃肠道的正常发育,并有助于在成年肠上皮的不断更新中调节组织分化,最近有报道在人胃......
The relationship between hypermethylation of CpG islands in the promoter regions of O6methylguanine DNA methyltransferas......
目的 探讨胱硫醚-β-合酶(CBS)启动子区的超甲基化与基因表达及功能的相关性.方法 通过结合重亚硫酸盐处理的直接测序、实时定量聚......
Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in ga
AIM: To identify the methylation of secreted frizzledrelated protein 1 (SFRP1) in gastric cancer and to investigate the ......
AIM: To determine pl6 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on pl6-protein e......
Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic can
AIM:To determine the methylation status and aberrant expression of some secreted frizzled-related protein (SFRP) genes i......
Pancreatic cancer is one of the malignant tumor with a very poor prognosis. Both genetic and epigenetic alterations are ......
Aberrant p16 promoter hypermethylation in bronchial mucosae as a biomarker for the early detection o
Lung cancer is the leading cause of cancer related death in the world and its mortality could be greatly reduced by diag......
DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用。文中主要综述了几十年来人们对DNA甲基化异常与基因转录及......
Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in ga
BACKGROUND Aberrant methylation in DNA regulatory regions could downregulate tumor suppressor genes without changing the......
目的探讨原发性结肠腺癌组织与相应癌旁组织中E-cadherin（E-cad）基因异常甲基化改变及其蛋白表达的特点。以及其与结肠腺癌发生发展......
Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic can
瞄准：为了决定甲基化地位和一些的异常表示，在胰腺的癌症分泌了卷发相关的蛋白质(SFRP ) 基因并且在胰腺的致癌作用探索他们的角色。......
瞄准：在胃的弦音器决定 p16 倡导者 hypermethylation 口头的织物和浆液样品，它 p16 蛋白质表示上的影响，和与临床、组织学的特征的关......
染色质解旋酶DNA结合蛋白5（CHD5）属于染色质重塑酶,其既能重塑染色质促进基因转录,又能正向调控p53/p19arf控制细胞增殖、凋亡和衰老......
目的：Eph基因和配体在多种肿瘤中呈高表达，并可能在肿瘤的发生、发展及预后中发挥重要作用。作者探讨EphA7基因在大肠癌细胞系和结直......
这研究的目的是在膀胱 urothelial 癌组织决定在 DACT1 基因倡导者和更低的 mRNA 表示的 hypermethylation 之间的关系。29 件 uro......
人类肿瘤的发生是多基因、多步骤共同作用的结果,抑癌基因在这一进程中扮演着重要的角色。最新研究表明,在肿瘤形成过程中,启动子......
RASSFIA Promoter Hypermethylation as a Prognosis and Diagnosis for Breast Cancer in Vietnamese Popul
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目的检测不同类型脑肿瘤患者肿瘤组织和血浆DNA中P16基因启动子区CpG岛甲基化状态，探讨P16基因甲基化与脑肿瘤发生发展的关系以及血......
目的探讨降钙素（ＣＴ）基因高度基化在恶性血液病中的临床意义。方法，用限制性内切酶（ＨＰａⅡ）消化ＤＮＡ，应用多聚酶链反应（ＰＣＲ）技术检测了７３例恶性血液病和对照......
乙型肝炎病毒（hepatitis B virus,HBV）感染引起多种抑癌基因启动子甲基化已有广泛的研究和报道,本文从体内和体外研究总结了目前与HB......
P15基因是肿瘤抑制基因的侯选基因,受细胞生长抑制蛋白TGF-β的诱导,编码周期素依赖激酶4/6(CDK4/6)抑制因子,对细胞周期起负调控......
目的：O^6－甲基鸟嘌呤DNA甲基转移酶（MGMT）可以转移DNA加合物O^6－甲基鸟嘌呤中的甲基，从而修复DNA损伤，许多肿瘤中发现MGMT基因启动子过甲......
目的：研究 p16基因在脑胶质瘤中的纯合性缺失、高甲基化和突变等结构变化及其与表达之间的关系。方法：应用聚合酶链反应（ polymerase ......
DNA甲基化是哺乳动物基因组最常见的修饰方式,它存在于生物体正常的生理过程,DNA异常甲基化和疾病的发生发展有关.该文综述了癌症......
No Association between p53 Immunohistochemical Staining and RASSF1 or DAPK1 Hypermethylation in Non-
p53 mutations have been linked with shortened survival rates in non-small cell lung cancer (NSCLC). Hypermethylation of ......
No Association between p53 Immunohistochemical Staining and RASSF1 or DAPK1 Hypermethylation in Non-
p53 mutations have been linked with shortened survival rates in non-small cell lung cancer (NSCLC). Hypermethylation of ......
The role of XPC protein deficiency in tobacco smoke-induced DNA hypermethylation of tumor suppressor
DNA hypermethylation of tumor suppressor genes has been frequently observed in cancer patients, and therefore, may provi......
Endometrial cancer is the seventh most common cancer worldwide among females and accounts for about 40% of cancers of th......
Introduction: Downstream of tyrosine kinase 7 (DOK-7) is a member of the DOK family, which has been associated with the ......
目的：探讨miR-145高甲基化在非小细胞肺癌（non-small cell lungcancer,NSCLC）组织中检测的意义。方法：收集2012年5月至2015年1月在我院......
Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K-ras, c-my
In a total of 83 UN specimens were investigated for proto-oncogene mutations, tumor supressor genes promoter methylation......
